The CHOP PediSeq Project

The Pediatric Clinical Sequencing Project

Autosomal Dominant Inheritance

Autosomal dominant inheritance refers to disorders that are due to having one copy of a gene with a mutation that causes the gene to not work properly. Autosomal dominant disorders are caused by mutations in genes that are on one of the pairs of non-sex chromosomes. The disease-causing mutation may be inherited from a parent who also has the condition. It might also be due to a new change that occurs in the egg or sperm that made the affected person. Anyone having an autosomal dominant condition has a 50% (1 in 2) chance of passing the condition on each time he or she has a child, and a 50% chance of NOT passing on the condition. The diagram above shows how this happens.






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